STEP 1 trial results

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Adults with overweight or obesity without diabetes.

Wegovy injection

Double-blind, placebo-controlled. Treatment-policy analysis.

Mean body weight change at 68 weeks

Mean body weight change at 68 weeks
Trial arm	Result
Semaglutide 2.4 mg	−14.9%
Placebo	−2.4%

Participants who lost at least 5% of body weight at week 68
Trial arm	Result
Semaglutide 2.4 mg	86.4%
Placebo	31.5%

Stopped treatment due to gastrointestinal events
Trial arm	Result
Semaglutide 2.4 mg	4.5%
Placebo	0.8%

Safety. Gastrointestinal events led 4.5% of the semaglutide group and 0.8% of the placebo group to stop treatment.