STEP 5 trial results

Name: DarDoc Abu Dhabi
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Adults with overweight or obesity without diabetes.

Wegovy injection

Double-blind, placebo-controlled. Both groups received behavioural support. Treatment-policy analysis.

Mean body weight change at 104 weeks

Mean body weight change at 104 weeks
Trial arm	Result
Semaglutide 2.4 mg	−15.2%
Placebo	−2.6%

Participants who lost at least 5% of body weight at week 104
Trial arm	Result
Semaglutide 2.4 mg	77.1%
Placebo	34.4%

Participants who reported gastrointestinal events
Trial arm	Result
Semaglutide 2.4 mg	82.2%
Placebo	53.9%

Safety. Gastrointestinal events were mostly mild or moderate.